Chemistry

HMWK 1 Pharmacology BIO 107

1) Paracelsus is known for what statement

2) Define Pharmacology

3) What are the advantages of prescription drugs

What are the Disadvantages

4) What are the advantages of Over-the-Counter Drugs?

What are the disadvantages?

5) What did the The Biologics Control Act of 1902 mandate?

6) What did the Pure Food and Drug Act of 1906 mandate?

7) What did the Sherley Amendment of 1912 mandate?

8) What did the Food, Drug, and Cosmetic Act (1938) and amendments mandate?

9) Why is thalidomide significant in the history of the FDA? Name the Doctor involved.

10) What is the Center for Drug Evaluation and Research

11) Define the four phases of clinical drug research

Phase I: Pharmacokinetic Study

Phase II: Dose Ranging in Patients

Phase III: Efficacy Study in Patients

Review of new drug application (NDA)

Phase IV: Postmarketing surveillance

12) What is Preclinical Investigation?

13) How are oral Generic Drugs tested?

14) Define Addiction

15) Define Dependence

16) Define Physical dependence

17) Define Psychologically dependent

18) Why are drugs placed on schedules?

19) Define each schedule

a. I

b. II

c. III

d. IV

e. V

20) What does the Center for Drug Evaluation and Research

21) What are the Five Rights used as the basis of safe delivery of medications

22) List common abbreviations used to convey drug dosing information

23) Which dosage forms cannot be crushed

24) What are the disadvantages/advantages of oral administration

25) What are the disadvantages/advantages of the sublingual route of administration

26) What are the disadvantages/advantages of using a locally acting drugs

27) What are the disadvantages/advantages of Parenteral route of administration

28) Define ADME

29) Define diffusion

30) What determines whether or not drugs should be taken on an empty stomach? Provide a detailed answer.

31) What determines whether or not drugs can pass through a membrane?

32) Describe enzyme induction in drug metabolism

33) What is first pass metabolism?

34) How does binding to plasma proteins affect the pharmacokinetics of a drug?

35) What is the therapeutic range of a drug, what is the therapeutic index?

36) What is the half life of a drug?

37) What is a Loading Dose?

38) What does a drug do to a receptor that functions as a enzyme

39) What does a drug do to a receptor that is coupled to a G-protein

40) What does a drug do to a receptor that is coupled to an ion channel

41) What is cAMP?

42) What is different about steroid receptors

43) How does receptor occupancy relate to efficacy

44) Compare and contrast potency and efficacy

45) Define Agonist and Antagonist

46) What are the ED50 & LD50

47) Define Therapeutic Index

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