Chemistry

HOW TO WRITE AN ABSTRACT Original research manuscript abstract One-Step Cyclization: Synthesis of N‑Heteroalkyl‑N′‑tosylpiperazines Jianying Huang,*,† Weiyuan Xu,† Hujun Xie,† and Shijun Li*,‡

†College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, P. R. China ‡College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, P. R. China

*S Supporting Information

ABSTRACT: Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries. Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process. Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and esterextended, tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants. On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (SN2) in the cyclization has been postulated and evidence for the formation of a six- membered ring has also been confirmed by means of density functional theory (DFT) calculations.

LET’S ANALYZE IT “Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries.” This first sentence explains why the work done in the paper is important. It is telling us that the compounds are valuable because they are intermediates in organic synthesis. “Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process”. In this part they explain what is the limitation of the current techniques/approaches. This justifies and underlines the importance of their work. They are trying to overcome current issues. “Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and ester extended, tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants.” This is a brief summary of their work and their potential use in pharmaceutical companies, underlining one more time the advantage of their approach “On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (SN) in the cyclization has been postulated and evidence for the formation of a six-membered ring has also been confirmed by means of density functional theory (DFT) calculations”. This is a brief statement about their study with conclusions on the mechanism

LET’S COMBINE THE INFORMATION WE GOT SO FAR

o The abstract is concise. Some journals have a maximum number of words allowed, some allow schemes or figures.

o It is important that it underlines the importance of the research conducted, “why this is valuable” o It should present a brief summary of the work o It should reiterate, in the conclusion section, the innovation of the approach and the value for

the field LET’S PRACTICE USING ONE OF OUR EXPERIMENTS AS AN EXAMPLE

NOTE:

o Our experiment does not involve original research, so it is not possible to talk about the innovation of our approach.

o Scientific papers are written in passive form (ex. “the compound was synthesized” instead of “we synthesized the compound”). Abstract, however, can be written using the present/past tense.

It states the importance of SN2 reactions and the significance of

purification techniques. Problem to address: it is hard to obtain pure

compounds after the synthesis

Summary of your experiment, with

results (yield and purity)

Conclusions: state again the

importance of your work

SN2 reactions are widely utilized in organic synthesis laboratory as well as in pharmaceutical companies for the synthesis of many organic intermediates. Purification of organic compounds from reaction mixture is sometimes time consuming and complicated. In this experiment we synthesized 1-bromobutane via an SN2 reaction and we purified the desired compound utilizing a combination of distillation and extraction. Analysis was conducted utilizing gas chromatography. The compound had a retention time of X min, and it was X% pure. In conclusion, this protocol was successful for the synthesis, and purification of 1-bromobutane showing the importance of conducting successive purification steps.

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