Biology                                        Published  February  2016

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ABOUT THIS WORKSHEET This worksheet complements the Click and Learn “The Eukaryotic Cell Cycle and Cancer” and is intended as a straightforward introduction to the cell cycle and how that relates to cancer. For a more comprehensive student worksheet, please see the in depth version.

PROCEDURE Read through the Click and Learn at ( cancer) to learn about the cell cycle. Answer the questions below. Click on the “Background” tab on the right side. Read the information and watch the videos. 1. Why is cell division important for both unicellular and multicellular organisms?

2. Why does cell division remain important to an adult organism even after it is fully developed?

3. Cells divide, differentiate, or die. What is differentiation?

4. What is apoptosis? What is its purpose?

5. What are cell cycle regulators?

6. What happens if cell cycle regulators don’t function properly?                                        Published  February  2016

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Click on the purple section labeled “Cell Cycle Phases” as well as the words “Mitosis” and “Interphase” to read an overview of the cell cycle. You can also click on the various phases. 7. Cells go through periods of growth and division. Cell division occurs during _______________.

8. The rest of the cell cycle is called interphase, during which _____________________________


9. Fill in the details about what happens during the three phases of interphase labeled in the


10. In general, what is the purpose of a checkpoint in the cell cycle?                                        Published  February  2016

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11. What is the G0 phase of the cell cycle? Which factors determine whether a cell enters G0? Can cells leave G0?

Click on “Cell Cycle Regulators and Cancer” in the center purple circle. Read the Regulators Overview and then read through the Cancer Overview and watch the videos. 12. What are cell cycle regulators?

a. Stimulatory proteins are encoded by _________________________________. Examples include: ______________________________________________________

b. Inhibitory proteins are encoded by ___________________________________________. Examples include: ______________________________________________________

13. Cancer is the result of an improperly regulated cell cycle. Describe two reasons why cells can form tumors.

14. In some types of colon cancer, stem cells have a mutation in the APC gene. What happens if the APC gene is mutated?

15. Normally, proto-oncogenes stimulate the cell cycle. What are oncogenes and how do they affect the cell cycle?                                        Published  February  2016

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a. To cause cancer, proto-oncogenes require _________ allele(s) to be mutated and therefore are considered ____________________. The mutation results in a __________ of function.

16. Normally, tumor suppressor genes inhibit the cell cycle. How do mutated tumor suppressor genes affect the cell cycle?

a. To cause cancer, tumor suppressor genes require _________ allele(s) to be mutated and therefore are considered ____________________. The mutation results in a __________ of function.

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