Biology

BOS 4201, Toxicology 1

Course Description Exploration of the basic principles associated with the toxic effects of chemicals on the living organism while examining the regulatory aspects and applications of toxicology in the workplace. Among the topics covered are the potential adverse effects of drugs, pesticides, food additives, and industrial chemicals.

Course Textbook Richards, I. S., & Bourgeois, M. M. (2014). Principles and practice of toxicology in public health (2nd ed.). Burlington, MA:

Jones & Bartlett.

Course Learning Outcomes Upon completion of this course, students should be able to:

1. Describe the foundational aspect of toxicology, including the history, terminology, and the basic concepts. 2. Explain the absorption, distribution, and excretion of chemical compounds in biological systems. 3. Assess the environmental risk from the presence of chemical compounds based on their toxicity category. 4. Relate the characteristics of different types of drugs to their toxicity. 5. Examine toxicity hazards related to exposure to various types and classes of hazardous substances. 6. Explain the uses and limitations of product labeling for public safety. 7. Summarize the impact of exposure to various types of environmental pollution. 8. Explain the toxic effects of natural products on target organs of the body. 9. Discuss the objectives of toxicity testing and the endpoints.

Credits Upon completion of this course, the students will earn three (3) hours of college credit.

Course Structure

1. Unit Learning Outcomes: Each unit contains Learning Outcomes that specify the measurable skills and knowledge students should gain upon completion of the unit.

2. Unit Lesson: Each unit contains a Unit Lesson, which discusses unit material. 3. Reading Assignments: Each unit contains Reading Assignments from one or more chapters from the textbook.

Chapter presentations are provided in each unit study guide as Suggested Reading to aid students in their course of study. Suggested Readings are listed in the unit study guides to aid students in their course of study. The readings themselves may or may not be provided in the course, but students are encouraged to read the resources listed if the opportunity arises as they have valuable information that expands upon the lesson material. Students will not be tested on their knowledge of the Suggested Readings.

4. Learning Activities (Non-Graded): These non-graded Learning Activities are provided in each unit to aid students in their course of study.

5. Discussion Boards: Discussion Boards are a part of all CSU term courses. Information and specifications regarding these assignments are provided in the Academic Policies listed in the Course Menu bar.

6. Unit Assessments: This course contains five Unit Assessments, one to be completed at the end of Units I-IV and VIII. Assessments are composed of multiple-choice questions and written response questions.

BOS 4201, Toxicology Course Syllabus

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7. Unit Assignments: Students are required to submit for grading Unit Assignments in Units III and V-VII. Specific information and instructions regarding these assignments are provided below. Grading rubrics are included with each assignment. Specific information about accessing these rubrics is provided below.

8. Ask the Professor: This communication forum provides you with an opportunity to ask your professor general or course content related questions.

9. Student Break Room: This communication forum allows for casual conversation with your classmates.

CSU Online Library There is a virtual library with resources, including both journals and ebooks, to support your program and your course at Columbia Southern University. eResources are accessible 24 hours a day/7 days a week from the CSU Online Library gateway page. To access the library, log into myCSU, and then click on CSU Online Library. Resources are organized in the library by title, but if you click on Research Guides, you will find eResources arranged by subject. The Library Reference service is available 7 days a week; you can reach CSU’s virtual librarians by emailing thevirtuallibrarian@columbiasouthern.edu. These professional librarians will be glad to help you develop your research plan or to assist you in any way in finding relevant, appropriate, and timely information. Librarian responses may occur within minutes or hours, but it will never take more than 24 hours for a librarian to send a response to the email address you have provided. Replies to reference requests may include customized keyword search strategies, links to videos, research guides, screen captures, attachments, a phone call, live screen sharing, and meeting room appointments, as well as other forms of instruction.

Unit Assignments Unit III Article Critique You are to choose an article from the CSU Online Library database. The article may cover a topic presented in this unit. The article itself must be more than one page in length. Some suggested topics include:

 environmental case studies,

 environmental toxicology,

 environmental chemistry,

 environmental exposure to pollutants,

 persistent chemicals in the environment,

 environment and toxicology, or

 pollution and health effects. The assignment must include the following components:

1. a brief introduction to the article, 2. a summary and analysis of the key points of the article, 3. a decision on whether or not the article supports the concepts as presented in the textbook, and 4. a summary of the article’s conclusions and your own opinions.

The assignment must be a minimum of two pages but no more than four pages in length, double-spaced, and in APA style. Ensure you use APA references and in-text citations in your critique. Information about accessing the Blackboard Grading Rubric for this assignment is provided below.

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Unit V: Literature Review The topic for this unit was the classification of carcinogens by the International Agency for Research on Cancer (IARC). For this assignment, pick a group 1 carcinogen from the IARC. Find at least five peer-reviewed journal articles that support the relationship between the carcinogen and the cancer that it causes. Some suggested topics might be

 benzene and leukemia,

 crystalline silica dust and lung cancer, or

 vinyl chloride and liver cancer. The Business Source Complete database is a good source of journals for safety-related articles from the CSU Online Library. The Literature Review must include the following components:

 an introduction of your topic of choice (include some background information on the origins of exposure and cancer),

 the methods used to search for the articles,

 the results of the articles,

 a discussion and conclusion with your own opinion, and.

 APA references and in-text citations for the article. The literature review must be three to four pages in length and follow APA formatting. Information about accessing the Blackboard Grading Rubric for this assignment is provided below. Unit VI: Case Study Animal use in toxicity testing has long been a controversial issue, however, there can be benefits. Read “The Use of Animals in Research,” which is an article that can be retrieved from http://www.toxicology.org/pubs/docs/air/AIR_Final.pdf. Evaluate the current policies outlined in the Position Statement. Use the instructions to guide you in your analysis. Feel free to use additional information and avenues of information, including the textbook, to critically analyze this policy. In addition, answer the following questions:

 How do toxicologists determine which exposures may cause adverse health effects?

 How does the information apply to what you are learning in the course?

 What were the objectives of this toxicity testing?

 What were the endpoints of this toxicity testing?

Finally, include weather or not you agree with the Society of Toxicology’s position on animal testing. Your Case Study assignment should be three to four pages in length. Use APA style guidelines in writing this assignment, following APA rules for formatting, quoting, paraphrasing, citing, and referencing. Information about accessing the Blackboard Grading Rubric for this assignment is provided below. Unit VII: PowerPoint Presentation Create an eight- to ten-slide presentation about the uses and limitations of product labeling for public safety. You can use the information from your textbook, as well as information from other reliable sources (Note that unmonitored websites, such as Wikipedia, are not acceptable.). Access the CSU Online Library for the additional resources. Be creative and add photos, images or other supplemental graphics to support your presentation. Ensure you that you use images from the public domain or creative commons. Be sure to cite any sources used in a reference slide, using proper APA formatting. You may also use the slide notes function to explain slide contents as necessary.

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The following are ideas for topics you may want to address:

 the purpose of product labeling,

 product labeling requirements,

 limitations of product labels,

 pesticide product labeling, and

 federal food and drug requirements for labeling. Information about accessing the Blackboard Grading Rubric for this assignment is provided below.

APA Guidelines CSU requires that students use APA style for papers and projects. Therefore, the APA rules for formatting, quoting, paraphrasing, citing, and listing of sources are to be followed. Students can find CSU’s Citation Guide in the myCSU Student Portal by clicking on the “Citation Resources” link in the “Learning Resources” area of the myCSU Student Portal. This document includes examples and sample papers and provides information on how to contact the CSU Success Center.

Blackboard Grading Rubrics Assignment Rubrics One or more assignments in this course utilizes a Blackboard Grading Rubric. A rubric is a tool that lists evaluation criteria and can help you organize your efforts to meet the requirements of an assignment. Your professor will use the Blackboard Grading Rubric to assign points and provide feedback for the assignment. You are encouraged to view the assignment rubric before submitting your work. This will allow you to review the evaluation criteria as you prepare your assignments. You may access the rubric in “My Grades” through the “Tools” button in your course menu. Click the “View Rubric” link to see the evaluation criteria for the assignment. Upon receiving your assignment grade, you may view your grade breakdown and feedback in the rubric.

CSU Grading Rubrics for Papers/Projects, Discussion Boards, and Assessments The Learning Resource area of the myCSU Student Portal provides the rubrics, and information on how to use them, for Discussion Boards, written response questions in Unit Assessments, and Research Papers/Projects. The course writing assignments will be graded based on the CSU Grading Rubric for all types of writing assignments, unless otherwise specified within assignment instructions. In addition, all papers will be submitted for electronic evaluation to rule out plagiarism. Course projects will contain project-specific grading criteria defined in the project directions. To view the rubrics, click the Academic Policies link on the Course Menu, or access them through the CSU Grading Rubric link found in the Learning Resources area of the myCSU Student Portal.

Communication Forums These are non-graded discussion forums that allow you to communicate with your professor and other students. Participation in these discussion forums is encouraged, but not required. You can access these forums with the buttons in the Course Menu. Instructions for subscribing/unsubscribing to these forums are provided below. Click here for instructions on how to subscribe/unsubscribe and post to the Communication Forums. Ask the Professor This communication forum provides you with an opportunity to ask your professor general or course content questions. Questions may focus on Blackboard locations of online course components, textbook or course content elaboration, additional guidance on assessment requirements, or general advice from other students.

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Questions that are specific in nature, such as inquiries regarding assessment/assignment grades or personal accommodation requests, are NOT to be posted on this forum. If you have questions, comments, or concerns of a non- public nature, please feel free to email your professor. Responses to your post will be addressed or emailed by the professor within 48 hours. Before posting, please ensure that you have read all relevant course documentation, including the syllabus, assessment/assignment instructions, faculty feedback, and other important information. Student Break Room This communication forum allows for casual conversation with your classmates. Communication on this forum should always maintain a standard of appropriateness and respect for your fellow classmates. This forum should NOT be used to share assessment answers.

Grading

Discussion Boards (8 @ 1%) = 8% Unit Assessments (5 @ 4%) = 20% Unit III Article Critique = 12% Unit V Literature Review = 25% Unit VI Case Study = 30% Unit VII PowerPoint Presentation = 5% Total = 100%

Course Schedule/Checklist (PLEASE PRINT) The following pages contain a printable Course Schedule to assist you through this course. By following this schedule, you will be assured that you will complete the course within the time allotted.

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BOS 4201, Toxicology Course Schedule

By following this schedule, you will be assured that you will complete the course within the time allotted. Please keep this schedule for reference as you progress through your course.

Unit I The History and Basic Concepts of Toxicology

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 1:Toxicology and Its Roots as a Science  Click here to access the Chapter 1 PowerPoint presentation. Click here to access a PDF version of the

presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Assessment by Tuesday, Midnight (Central Time)

Notes/Goals:

Unit II Factors That Modify Toxic Responses and Natural Sources of Toxins

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 3: Toxicity and the Factors That Modify Toxic Responses  Click here to access the Chapter 3 PowerPoint presentation. Click here to access a PDF version of the

presentation.  Chapter 4: Biological Poisons: Plant and Animal Toxins  Click here to access the Chapter 4 PowerPoint presentation. Click here to access a PDF version of the

presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Assessment by Tuesday, Midnight (Central Time)

Notes/Goals:

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BOS 4201, Toxicology Course Schedule

Unit III Environmental Risks

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 5: Environmental Pollutants and Their Fate  Click here to access the Chapter 5 PowerPoint presentation. Click here to access a PDF version of the

presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Assessment by Tuesday, Midnight (Central Time)  Article Critique by Tuesday, Midnight (Central Time)

Notes/Goals:

Unit IV Absorption, Distribution and Elimination of Chemical Compounds

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 7: Absorption of Toxicants and Models of Disposition  Click here to access the Chapter 7 PowerPoint Presentation. Click here to access a PDF version of

the presentation.  Chapter 8: Distribution, Storage, and Elimination of Toxicants  Click here to access the Chapter 8 PowerPoint Presentation. Click here to access a PDF version of

the presentation.  Chapter 9: Biotransformation  Click here to access the Chapter 9 PowerPoint Presentation. Click here to access a PDF version of

the presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Assessment by Tuesday, Midnight (Central Time)

Notes/Goals:

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BOS 4201, Toxicology Course Schedule

Unit V Mutagenesis and Carcinogenesis

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 10: Chemical-Induced Mutagenesis  Click here to access the Chapter 10 PowerPoint Presentation. Click here to access a PDF version of

the presentation.  Chapter 11: Chemicals and Cancer  Click here to access the Chapter 11 PowerPoint Presentation. Click here to access a PDF version of

the presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Literature Review by Tuesday, Midnight (Central Time)

Notes/Goals:

Unit VI Toxicity Testing

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 21: Toxicity Testing  Click here to access the Chapter 21 PowerPoint Presentation. Click here to access a PDF version of

the presentation.  Appendix 21-1: Example of a Template for a Subchronic Toxicity Study in Rodents for FDA Review  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Case Study by Tuesday, Midnight (Central Time)

Notes/Goals:

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BOS 4201, Toxicology Course Schedule

Unit VII Product Labeling

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 22: Uses and Limitations of Product Labeling for Public Safety  Click here to access the Chapter 22 PowerPoint presentation. Click here to access a PDF version of

the presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  PowerPoint Presentation by Tuesday, Midnight (Central Time)

Notes/Goals:

Unit VIII Toxicology Principles in the Management of Acute Poisonings

Review:  Unit Study Guide  Learning Activities (Non-Graded): See Study Guide

Read:

 Chapter 23: Toxicology Principles in the Management of Acute Poisonings  Click here to access the Chapter 23 PowerPoint presentation. Click here to access a PDF version of

the presentation.  Suggested Reading: See Study Guide

Discuss:

 Discussion Board Response: Submit your response to the Discussion Board question by Saturday, Midnight (Central Time)

 Discussion Board Comment: Comment on another student’s Discussion Board response by Tuesday, Midnight (Central Time)

Submit:  Assessment by Tuesday, Midnight (Central Time)

Notes/Goals:

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